--- a/Lib/sysconfig.py
+++ b/Lib/sysconfig.py
@@ -36,6 +36,30 @@
         'scripts': '{base}/bin',
         'data': '{base}',
         },
+    'deb_system': {
+        'stdlib': '{installed_base}/lib/python{py_version_short}',
+        'platstdlib': '{platbase}/lib/python{py_version_short}',
+        'purelib': '{base}/lib/python3/dist-packages',
+        'platlib': '{platbase}/lib/python3/dist-packages',
+        'include':
+            '{installed_base}/include/python{py_version_short}{abiflags}',
+        'platinclude':
+            '{installed_platbase}/include/python{py_version_short}{abiflags}',
+        'scripts': '{base}/bin',
+        'data': '{base}',
+        },
+    'posix_local': {
+        'stdlib': '{installed_base}/lib/python{py_version_short}',
+        'platstdlib': '{platbase}/lib/python{py_version_short}',
+        'purelib': '{base}/local/lib/python{py_version_short}/dist-packages',
+        'platlib': '{platbase}/local/lib/python{py_version_short}/dist-packages',
+        'include':
+            '{installed_base}/include/python{py_version_short}{abiflags}',
+        'platinclude':
+            '{installed_platbase}/include/python{py_version_short}{abiflags}',
+        'scripts': '{base}/local/bin',
+        'data': '{base}/local',
+        },
     'posix_home': {
         'stdlib': '{installed_base}/lib/python',
         'platstdlib': '{base}/lib/python',
@@ -183,7 +207,7 @@
 _PYTHON_BUILD = is_python_build(True)
 
 if _PYTHON_BUILD:
-    for scheme in ('posix_prefix', 'posix_home'):
+    for scheme in ('posix_prefix', 'posix_home', 'posix_local', 'deb_system'):
         # On POSIX-y platforms, Python will:
         # - Build from .h files in 'headers' (which is only added to the
         #   scheme when building CPython)
@@ -237,8 +261,20 @@
             'home': 'posix_home',
             'user': 'osx_framework_user',
         }
+
+    if sys.base_prefix != sys.prefix or hasattr(sys, "real_prefix"):
+        # virtual environments
+        prefix_scheme = 'posix_prefix'
+    else:
+        # default to /usr for package builds, /usr/local otherwise
+        deb_build = os.environ.get('DEB_PYTHON_INSTALL_LAYOUT', 'posix_local')
+        if deb_build in ('deb', 'deb_system'):
+            prefix_scheme = 'deb_system'
+        else:
+            prefix_scheme = 'posix_local'
+
     return {
-        'prefix': 'posix_prefix',
+        'prefix': prefix_scheme,
         'home': 'posix_home',
         'user': 'posix_user',
     }
@@ -538,7 +574,7 @@
         else:
             inc_dir = _sys_home or _PROJECT_BASE
     else:
-        inc_dir = get_path('platinclude')
+        inc_dir = get_path('platinclude', 'posix_prefix')
     return os.path.join(inc_dir, 'pyconfig.h')
 
 
--- a/Lib/test/test_sysconfig.py
+++ b/Lib/test/test_sysconfig.py
@@ -263,7 +263,7 @@
         self.assertTrue(os.path.isfile(config_h), config_h)
 
     def test_get_scheme_names(self):
-        wanted = ['nt', 'posix_home', 'posix_prefix']
+        wanted = ['deb_system', 'nt', 'posix_home', 'posix_local', 'posix_prefix']
         if HAS_USER_BASE:
             wanted.extend(['nt_user', 'osx_framework_user', 'posix_user'])
         self.assertEqual(get_scheme_names(), tuple(sorted(wanted)))
